Bowel cancer that spreads to the lining of the inside of the abdomen (peritoneum) has previously been regarded as incurable. Traditionally this type of tumour spread has been treated with chemotherapy, which is frequently of limited benefit.
There is evidence that some patients with colon cancer that has spread to the abdomen can be cured by a combination of extensive surgery and heated chemotherapy wash during the operation (HIPEC). A number of units in the UK (Basingstoke, Christie, Birmingham, Dublin and Dundee) now offer this surgery and HIPEC as a treatment option.
It is important to find out which patients are most likely to benefit from this surgery and HIPEC for bowel cancer. To do that we have created a multi-site registry that documents details of patients with colorectal cancer that has spread to the peritoneum who have undergone CRS and HIPEC and their outcomes.
This will be a 3 year project to collect data and investigate the outcomes for patients undergoing this extensive procedure.
- Sedeghi B, Arvieux C, Glehen O et al. ) Peritoneal carcinomatosis from non-gynecologic malignancies: results of the EVOCAPE 1 multicentric prospective study. Cancer 2000, 88: 358–363.
- Mirnezami R, Mehta AM, Charndrakumaran K et al. Cytoreductive surgery in combination with hyperthermic intraperitoneal chemotherapy improves survival in patients with colorectal peritoneal metastases compared with systemic chemotherapy alone. Br J Cancer 2014, 111: 1500-08