Papers of interest

Below Pelican has listed a selection of papers that reflect the areas of research that we have been involved in and continue to support. Where possible the links to the abstracts are included for further information.

Magnetic resonance imaging prediction of an involved surgical resection margin in low rectal cancer. Salerno GV, Daniels IR, Moran BJ, Heald RJ, Thomas K, Brown G.Colorectal Disease. 2009 April; 52(4):632-9

MRI staging of low rectal cancer. Shihab OC, Moran BJ, Heald RJ, Quirke P, Brown G. European Radiology. 2009 March; 19 (3):643-50

Surgical management of rectal cancer: a multidisciplinary approach to technical and technological advances. Heald RJ. British Journal of Radiology. 2005; 78:128-30

Diagnostic accuracy of preoperative magnetic resonance imaging in predicting curative resection of rectal cancer: prospective observational study. MERCURY Study Group.BMJ. 2006;333:779

Magnetic Resonance Imaging–Detected Tumor Response for Locally Advanced Rectal Cancer Predicts Survival. Outcomes: MERCURY Experience. Patel UB, Taylor F, Blomqvist L, George C, Evans H, Tekkis P, Quirke P, Sebag-Montefiore D, Moran BJ, Heald RJ, Guthrie A, Bees N, Swift I, Pennert K,and Brown G. J Clin Oncol. 2011 Oct 1;29(28):3753-60

MRI After Treatment of Locally Advanced Rectal Cancer: How to Report Tumor Response—The MERCURY Experience. Uday B. Patel, Lennart K. Blomqvist, Fiona Taylor, Christopher George, Ashley Guthrie, Nicola Bees and Gina Brown. American Journal of Roentgenology 2012;199: W486-W495

Deferral of rectal surgery following a continued response to preoperative chemoradiotherapy (watch and wait) study: a phase II multicenter study in the United Kingdom. Yu SK, Brown G, Heald RJ, et al. J Clin Oncol . 2011; 29(4):abstract 489

A Systematic Approach to the Interpretation of Preoperative Staging MRI for Rectal Cancer. Fiona G. M. Taylor, Robert I. Swift, Lennart Blomqvist and Gina Brown. American Journal of Roentgenology. 2008;191: 1827-1835

Accurate staging, selective preoperative therapy and optimal surgery improves outcome in rectal cancer: a review of the recent evidence. Daniels IR, Fisher SE, Heald RJ and Moran BJ. Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland. 2007, 9(4):290-301

Sites of surgical wasting in the abdominoperineal specimen. Salerno G, Chandler I, Wotherspoon A, Thomas K, Moran BJ and Brown G. Br J Surg.2008. 95(9):1147-1154

Preoperative MRI sphincter morphology and anal manometry: can they be markers of functional outcome following anterior resection for rectal cancer? How P, Evans J, Moran B, Swift I and Brown G. Colorectal DiseaseL the Official Journal of the Association of Coloproctology of Great Britain and Ireland. 2012, 14(6):e339-45

Preoperative assessment of prognostic factors in rectal cancer using high‐resolution magnetic resonance imaging
G Brown, AG Radcliffe, RG Newcombe, NS Dallimore, MW Bourne, British Journal of Surgery 90 (3), 355-364

Diffusion MRI for prediction of response of rectal cancer to chemoradiation
A Dzik-Jurasz, C Domenig, M George, J Wolber, A Padhani, G Brown,The Lancet 360 (9329), 307-308

Neoadjuvant capecitabine and oxaliplatin followed by synchronous chemoradiation and total mesorectal excision in magnetic resonance imaging–defined poor-risk rectal cancer
I Chau, G Brown, D Cunningham, D Tait, A Wotherspoon, AR Norman. Journal of Clinical Oncology 24 (4), 668-674

Non‐invasive methods of assessing angiogenesis and their value in predicting response to treatment in colorectal cancer
ML George, ASK Dzik‐Jurasz, AR Padhani, G Brown, DM Tait, SA Eccles. British journal of surgery 88 (12), 1628-1636

Effectiveness of preoperative staging in rectal cancer: digital rectal examination, endoluminal ultrasound or magnetic resonance imaging?
G Brown, S Davies, GT Williams, MW Bourne, RG Newcombe. British journal of cancer 91 (1), 23-29

Extramural depth of tumor invasion at thin-section MR in patients with rectal cancer: results of the MERCURY study.
MERCURY Study Group. Radiology 243 (1), 132

MRI directed multidisciplinary team preoperative treatment strategy: the way to eliminate positive circumferential margins?
S Burton, G Brown, IR Daniels, AR Norman, B Mason, D Cunningham. British journal of cancer 94 (3), 351-357

High-resolution MRI of the anatomy important in total mesorectal excision of the rectum
G Brown, A Kirkham, GT Williams, M Bourne, AG Radcliffe, J Sayman. American Journal of Roentgenology 182 (2), 431-439

Non-operative treatment after neoadjuvant chemoradiotherapy for rectal cancer
BDP O’Neill, G Brown, RJ Heald, D Cunningham, DM Tait. The lancet oncology 8 (7), 625-633

Preoperative staging of rectal cancer
N Smith, G Brown. Acta oncologica 47 (1), 20-31

Colorectal hepatic metastases: quantitative measurements using single-shot echo-planar diffusion-weighted MR imaging. DM Koh, E Scurr, DJ Collins, A Pirgon, B Kanber, Karanjia, G.Brown. European radiology 16 (9), 1898-1905

Optimal total mesorectal excision for rectal cancer is by dissection in front of Denonvilliers’ fascia. RJ Heald, BJ Moran, G Brown, IR Daniels. British journal of surgery 91 (1), 121-123

Preoperative staging of rectal cancer: the MERCURY research project. G Brown, IR Daniels. Rectal Cancer Treatment, 58-74

Techniques and trouble-shooting in high spatial resolution thin slice MRI for rectal cancer. G Brown, IR Daniels, C Richardson, P Revell, D Peppercorn, M Bourne. British Institute of Radiology

Prognostic significance of magnetic resonance imaging‐detected extramural vascular invasion in rectal cancer. NJ Smith, Y Barbachano, AR Norman, RI Swift, AM Abulafi, G Brown. British Journal of Surgery 95 (2), 229-236

A systematic approach to the interpretation of preoperative staging MRI for rectal cancer. FGM Taylor, RI Swift, L Blomqvist, G Brown. American Journal of Roentgenology 191 (6), 1827-1835

MRI staging of low rectal cancer. OC Shihab, BJ Moran, RJ Heald, P Quirke, G Brown. European radiology 19 (3), 643-650

Thin section MRI in multidisciplinary pre-operative decision making for patients with rectal cancer. G Brown. British Institute of Radiology

Magnetic resonance imaging prediction of an involved surgical resection margin in low rectal cancer. GV Salerno, IR Daniels, BJ Moran, RJ Heald, K Thomas, G Brown. Diseases of the Colon & Rectum 52 (4), 632-639

Defining the surgical planes on MRI improves surgery for cancer of the low rectum. OC Shihab, RJ Heald, E Rullier, G Brown, T Holm, P Quirke, BJ Moran. The lancet oncology 10 (12), 1207-1211

Accuracy of CT prediction of poor prognostic features in colonic cancer. S Burton, G Brown, N Bees, A Norman, O Biedrzycki, A Arnaout. British Journal of Radiology 81 (961)

Will MRI provide maps of lines of excision for rectal cancer? A Radcliffe, G Brown. The Lancet 357 (9255), 495-496

Rectal cancer: the Basingstoke experience of total mesorectal excision, 1978-1997
RJ Heald, BJ Moran, RDH Ryall, R Sexton, JK MacFarlane
Archives of Surgery 133 (8), 894-898

Abdominoperineal excision of the rectum—an endangered operation
MRJ Heald, M Chir, RK Smedh, A Kald, R Sexton, BJ Moran
Diseases of the colon & rectum 40 (7), 747-751

Stoma‐related complications are more frequent after transverse colostomy than loop ileostomy: a prospective randomized clinical trial
DP Edwards, A Leppington‐Clarke, R Sexton, RJ Heald, BJ Moran
British journal of surgery 88 (3), 360-363

Postoperative adhesions: ten-year follow-up of 12,584 patients undergoing lower abdominal surgery
MC Parker, H Ellis, BJ Moran, JN Thompson, MS Wilson, D Menzies, …
Diseases of the colon & rectum 44 (6), 822-829

Predicting risk and diminishing the consequences of anastomotic dehiscence following rectal resection
JCJ Alberts, A Parvaiz, BJ Moran
Colorectal Disease 5 (5), 478-482

Total mesorectal excision results in low local recurrence rates in lymph node-positive rectal cancer
TD Cecil, R Sexton, BJ Moran, RJ Heald
Diseases of the colon & rectum 47 (7), 1145-1150

Definition and grading of anastomotic leakage following anterior resection of the rectum: a proposal by the International Study Group of Rectal Cancer
NN Rahbari, J Weitz, W Hohenberger, RJ Heald, B Moran, A Ulrich, …
Surgery 147 (3), 339-351

Response to ChemoRadiotherapy in Rectal Cancer – predictor of cure – and a crucial new choice for the patient. R.J.Heald, G.Beets & C.Carvalho. Colorectal Disease. 2014 may. 16(5): 334-337